Indications for instituting single-agent chemotherapy following evacuation of a hydatidiform mole usually include
A. A rise in HCG titersB. A plateau of HCG titers for 1 week
C. Return of HCG titer to normal at 6 weeks after evacuation
D. Appearance of liver metastasis
The
answer is a.
Single-agent chemotherapy is usually instituted if levels of hCG remain
elevated 8 weeks after evacuation of a hydatidiform mole. Approximately 50% of
the patients who have persistently high hCG titers will develop malignant
sequelae. If hCG titers rise or reach a plateau for 2 to 3 successive weeks
following molar evacuation, a single-agent chemotherapy should be instituted,
provided that thetrophoblastic disease has not metastasized to the liver or
brain. The presence of such metastases usually requires initiation of
combination chemotherapy.
