Which parameter adds predictive information regarding CVS risk stratification & measurement of serum cholesterol?
A. Anti-chlamydia pneumoniae antibodies
B. CRP
C. Homocysteine
D. Plasminogen activator inhibitor 1
A. Anti-chlamydia pneumoniae antibodies
B. CRP
C. Homocysteine
D. Plasminogen activator inhibitor 1
Ans.
B. C-reactive protein
Recent
studies have demonstrated that markers of inflammation correlate with coronary
risk and that inflammation plays a role in atheromatous plaque instability.
Elevations
of C-reactive protein, CRP identify patients at increased risk of myocardial
infarction MI and poor outcome of acute coronary syndromes. Measurement of CRP
adds information regarding risk stratification to standard risk factor such as
hypertension, diabetes, smoking, and lipids.
Elevations
in homocysteine, lipoprotein A, and plasminogen activator factor I have all
been associated with an increased risk at cardiovascular events; however, at
thi~ time none have been shown to be useful in populations to improve risk
stratification.
Recent
studies have suggested that infection with agents such as pneumoniae and
cytomegalovirus may playa role in the development of atherosclerosis.
To
date no studies have demonstrated a conclusive association, and early studies
looking at the utility of antibiotic treatment in coronary artery disease have
shown no benefit.
