In glomerular disease which of the following is manly excreted in Urine
A. Albumin.B. Globulin.
C. Light chain.
D. Heavy chain.
E. Tamm-Horsfall protein
Answer. A. Albumin ;
• Normally glomeruli of kidney does not
allow substances with MW >69,000.
When they are damaged or
diseased, they become more permeable
and plasma proteins may appear in urine.
• The smaller molecules of albumin
passes through damaged glomeruli more readily than the heavier
globulin, so albumin predominates in
urine.
• Light chains are filtered (MW. 25.000) freely in the glomeruli and
appears in urine (eg. Bence John
proteinuria in multiple myeloma).
• Heavy chains are (MW about 50.000)
also permeable across glomeruli.
