Anti Tubercular drug metabolism under genetic control | PGI based MCQs

Which antitubercular drug metabolism is under genetic control

A. Rifampicin 
B. INH 
C. Cyclosporine 
D. PZM 
E. Kanamycin

The Answer is. (B) INH

• INH is extremely metabolized by liver by acetylations and metabolites are excreted in urine. The rate of

acetylation of INH is under genetic control. The variations.

Fast acetylation

Slow acetylation note:

Rifampicin is metabolized in in liver to an active metaholite which is excreted mainly in bile and some in urine.
• Pyrizinamideis extensively metabolized in liver excreted in urine

• Kanamycin excreted unchanged by the kidney