Drugs inhibiting formation of purines | PGI based MCQs

Drugs inhibiting formation of purines :

A. 5-FU 
B. 6- mercaptopurine
C. Hydroxyurea
D. Methotrexate 
E. Cytosine arabinoside

The Answer is. (B) 6- mercaptopurine , (D) Methotrexate

• The purine antagonists are : 6 Mercaptopurine (6-MP)

                                Thioguanine (6-TG)

                                Azathiprine

• 5-FU cytnine arabinncid arepyrimidine antagonist

•Methotrexate is a folate antagonist that inhibit dihydrofolate reductase enzyme required for tetrahydrofolate

formation Tetrahydrofolate is used in Purine synthesis. Methotrexate limits the tetrahydrofolate available for purine synthesis.