Which is found in DiGeorge Syndrome?
A. TetanyB. Eczema
C. Mucocutaneous candidiasis
D. Absebnt B and Tcells
E. Total absence of T cells
The Answer is . (A) Tetany; (C) Mucocntaneous candidiasis
• Di George’s syndrome is a developmental defect
involving the endodermal derivative of 3rd and 4th pharyngeal pouches, whih
leads to aplasia or hypoplasia of
the thymus and parathyroid glands
• Circulating T-cells are reduced
• Tetany (hypocalcemic) can occur.
• Humoral immunity is largelyunaffected.
• Low immunity against viral and fungal infection ; mucocutaneous candidiasis occurs.
• Congential cardiac anomalies (Fallot’s tetralogv)
including great vessels of heart, facial deformities are prominent.
• Eczema is seen in
wiskot-Aidrich syndrome.
• The individuals have a small but histologically
normal thymus allowing most patients to develop functional T-cells
in number that may or may not be adequate for host
defense.
