Zell ballen pattern is typical of:
A. AstrocytomaB. Meningioma
C.Pheochromocytoma
D.Chondrosarcoma
Ans. (c).Phaeochromocytoma
• The
characteristic microscopic pattern of phaeochromocytoma is one of solid, round
“cell aggregates”
(Zeliballen), cords, ribbons or trabeculae separated by a rich fibrovascular stroma.
• Phaeochromocytomas are stained by antibodies to Neuron specific enolase, chromagranin
A, Synaptophysin
• They are calcitonin, VIP, Bombesin, somatostatin and serotonin positive invariably.
• Bilateral in 10% cases • Extraadrenal in 10% cases
• Familial in 10% cases • Malignant in 10% cases
• Multiple in 10% cases • turinary VMA levels seen.
• turinarymetanephrine • MIBG Scan is most specific and sensitive for diagnosis.
Associated with:
• MEN 2 syndromes
(Zeliballen), cords, ribbons or trabeculae separated by a rich fibrovascular stroma.
• Phaeochromocytomas are stained by antibodies to Neuron specific enolase, chromagranin
A, Synaptophysin
• They are calcitonin, VIP, Bombesin, somatostatin and serotonin positive invariably.
• Bilateral in 10% cases • Extraadrenal in 10% cases
• Familial in 10% cases • Malignant in 10% cases
• Multiple in 10% cases • turinary VMA levels seen.
• turinarymetanephrine • MIBG Scan is most specific and sensitive for diagnosis.
Associated with:
• MEN 2 syndromes
• Von
hippel landau syndrome
• Neurofibromatosis
•
Struge weber syndrome • Neurofibromatosis
