NIME Next Batch PGI Quest in Delhi from 10 August to 20 August
B. Increased estrogen due to decreased catabolism
C. Increased peripheral conversion of androgens into estrogen
D. Increased testosterone
E. None of the above
Hypogonadism in cirrhosis is due to
A. Direct effect of alcohol on testesB. Increased estrogen due to decreased catabolism
C. Increased peripheral conversion of androgens into estrogen
D. Increased testosterone
E. None of the above
Ans. A. Direct effect of alcohol on testes ; (B) Increased estrogen due to decreased catabolism; (C) Increased peripheral conversion of androgens into estrogen
• The testicular atrophy is due to disorder of hormonal metabolism or direct toxic effect on testis.
• In cirrhosis of liver a combined testicular and pituitary abnormality leads to decreased testosterone production. The decreased testosterone (i.e. androgen insufficiency) production most likely results from inhibition of LH secretion by estrogens in patients with chronic liver disease.
