Which of the following is the absolute finding of bone marrow biopsy?
A. Acute leukemiaB. Megaloblastic anemia
C. Hairy cell leukemia
D. Thalassemia
Ans. C. (Hairy cell leukemia)
Explanation
In hairy cell leukemia, the malignant cells appear to have “hairy” projections on light and electron microscopy and show a characteristic staining pattern with tartarate-resistant acid phosphatase. Bone marrow is typically not able to be aspirated, and biopsy shows a pattern of fibrosis with diffuse infiltration by the malignant cells.
In hairy cell leukemia, the malignant cells appear to have “hairy” projections on light and electron microscopy and show a characteristic staining pattern with tartarate-resistant acid phosphatase. Bone marrow is typically not able to be aspirated, and biopsy shows a pattern of fibrosis with diffuse infiltration by the malignant cells.
