Pancytopenia with cellular marrow is a feature of
A. PNHB. G6PD deficiency
C. Acquired aplastic anemia
D. Thalassemia
Ans. A. (PNH)
Explanation
It is the most consistent blood finding in anemia, which may range from mild to moderate to very severe. The anemia is usually normo-macrocytic, unremarkable red cell morphology; if MCV is high, it is usually largely accounted for by reticulocytosis, which may be quite marked (upto 20%, or upto 400,000/µL). Neutropenia and/or thrombocytopenia may or may not be present. In conjugated, bilirubin is mildly or moderately elevated, LDH is typically markedly elevated, and haptoglobin is usually undetectable. Hemoglobin urea may be overt in a random urine sample. The bone marrow is usually cellular with marked to massive erythroid hyperplasia, often with mild to moderate dyserythropoietic features. At some stage of the disease the marrow may become hypocellular or even frankly aplastic.
It is the most consistent blood finding in anemia, which may range from mild to moderate to very severe. The anemia is usually normo-macrocytic, unremarkable red cell morphology; if MCV is high, it is usually largely accounted for by reticulocytosis, which may be quite marked (upto 20%, or upto 400,000/µL). Neutropenia and/or thrombocytopenia may or may not be present. In conjugated, bilirubin is mildly or moderately elevated, LDH is typically markedly elevated, and haptoglobin is usually undetectable. Hemoglobin urea may be overt in a random urine sample. The bone marrow is usually cellular with marked to massive erythroid hyperplasia, often with mild to moderate dyserythropoietic features. At some stage of the disease the marrow may become hypocellular or even frankly aplastic.
