All of the following statements about mycosis fungoides are true EXCEPT
A. It is the most common form of cutaneous lymphomaB. Pautriers microabscess
C. Indolent course and easily amenable to treatment
D. Erythroderma seen and spreads to peripheral circulation
Ans. C.
(Indolent course and easily amenable to treatment)
Explanation
Mycosis fungoides is also known as cutaneous T-cell lymphoma. This lymphoma is more often seen by dermatologists. Median age is mid fifties, more common in males and in blacks. It is an indolent lymphoma with patient often having several years of eczematous or dermatitic skin lesions before the diagnosis is finally established. In advanced stages, the lymphoma can spread to lymph nodes and visceral organs. Patients with this lymphoma may develop generalized erythroderma and circulating tumor cells, called Sezary syndrome. Rare patients with localized early stage mycosis fungoides can be cured with radiotherapy, often total skin electron beam irradiation. More advanced disease has been treated with topical glucocorticoids, topical nitrogen mustard, phototherapy, psoralen with ultraviolet, an electron-beam irradiation (PUVA), interferon, antibodies, fusion toxins, and systemic cytotoxic therapy.
