Primary sclerosing cholangitis, true are:
a. ↑ Femalesb. Associated with IBD
c. Involves intra & extrahepatic ducts
d. ERCP not helpful
e. associated with autoimmunity mechanisms
Ans: (B) Associated with IBD; (C) Involves intra &
extrahepatic ducts; (E)
associated with autoimmunity mechanisms
Primary sclerosing cholangitis
(PSC) PSC is characterized by recurrent episodes of cholangitis (infection of
the bile ducts), with progressive biliary scarring and obstruction: PSC causes
inflammation and subsequent obstruction of bile ducts both at a intrahepatic
and extrahepatic level. The inflammation impedes the flow of bile to the gut,
which can ultimately lead to cirrhosis of the liver, liver failure and liver
cancer. The underlying cause of the inflammation is believed to be autoimmunity.
Strong association of those with
PSC to also have ulcerative colitis The definitive treatment is liver
transplantation.