Treatment of choice for typhoid fever is:-
A. Cephalexin
B. Gentamicin
C. Co-trimoxazole
D. Tetracycline
E. Ciprofloxacin
B. Gentamicin
C. Co-trimoxazole
D. Tetracycline
E. Ciprofloxacin
Ans.
(E) Ciprofloxacin:
• Till recently chloramphenicol was drug of choice for typhoid fever. But due to emergence of resistant- strains of S. Typhi, it is no longer used now a days.
• Due to emergence of MDR S. typhi — either quinolones or third-generation cephalosporins (e.g. ceftriaxone) are currently recommended for empirical antibiotic treatment.
• First and 2nd generation cephalosporins and aminoglycosides are ineffective.
• Drugs for chronic carrier — amoxycillin, TMP-SMX, Ciprofloxacin or Norfloxacin — shown 50-80% effective.
• S. typhi is now resistant to chloramphenicol, ampicillin, trimethoprim, Streptomycin, Sulfonamides, tetracycline
• Till recently chloramphenicol was drug of choice for typhoid fever. But due to emergence of resistant- strains of S. Typhi, it is no longer used now a days.
• Due to emergence of MDR S. typhi — either quinolones or third-generation cephalosporins (e.g. ceftriaxone) are currently recommended for empirical antibiotic treatment.
• First and 2nd generation cephalosporins and aminoglycosides are ineffective.
• Drugs for chronic carrier — amoxycillin, TMP-SMX, Ciprofloxacin or Norfloxacin — shown 50-80% effective.
• S. typhi is now resistant to chloramphenicol, ampicillin, trimethoprim, Streptomycin, Sulfonamides, tetracycline
