Drugs used for ovulation induction
A. Clomiphene citrateB. Danazol
C. Cyproterone acetate
D. Tamoxifen
E. Mefenemic Acid
Ans. (A) Clomiphene citrate ; (D) Tamoxifen
• The following drugs are used either single or in combination for induction of ovulation
— Stimulation of ovulation
• Clomiphene citrate (CC)
•FSH
•HCG
•GnRH
• GnRH analogues
— Reduction of level of:
• Androgen = Dexamethasone
• Prolactin = Bromocriptine
— Substitution therapy
•Hypothyroidism — Thyroid extract
•Diabetes mellitus Antidiabetic drugs.
• Tamoxifen is an anti-oestrogen, can be used where the patient is intolerant to clomiphene.
• Cyclofenil is a compound structurally similar to diethyl stilbestrol. It has got anti-oestrogenic property and it produces abundant thin, elastic cervical mucous which facilitate sperm penetration. The indications are same as that of clomiphene.
• Cyproterone acetate is an anti-androgenic progestogen. The compound blocks the hormone action at the receptorlevel. It decreases 5c reductase activity of reduces LH secretion.
It is used in idiopathic hirsutism or hyperandrogenic state.
