Genodermal disease that can cause skin malignancy are
A. Xeroderma pigmentosaB. Neurofibromatosis
C. Actinic keratosis
D. Porphyria cutanea tarda
E. None of the above
Ans. (A) Xeroderma pigmentosa;
• Xeroederama pigmentosa is a rare autosomal recessive neurocutaneous disorder in addition to
skin lesions, patients may show:-
- Progressive mental deterioration, microcephaly, ataxia, peripheral neuropathy, spasticity,
choreoathetosis, Hypogonadism and nerve deafness.
• Inheritable conditions a/w skin cancer
- Albinism
- Xeroderma pigmentosum
- Congenital nevus.
- BCC nevus syndrome
• Actinic keratosis is a premalignant skin lesion.
• Neurofibromatosis can undergo malignant changes to sarcoma & CNS tumours.
• Xeroederama pigmentosa is a rare autosomal recessive neurocutaneous disorder in addition to
skin lesions, patients may show:-
- Progressive mental deterioration, microcephaly, ataxia, peripheral neuropathy, spasticity,
choreoathetosis, Hypogonadism and nerve deafness.
• Inheritable conditions a/w skin cancer
- Albinism
- Xeroderma pigmentosum
- Congenital nevus.
- BCC nevus syndrome
• Actinic keratosis is a premalignant skin lesion.
• Neurofibromatosis can undergo malignant changes to sarcoma & CNS tumours.
