Biondi ring tangles are seen in
A. Lateral ventricleB. Cerebral cortex
C. Lining of the choroid plexus
D. Cerebellum
Ans. C. (Lining of the choroid plexus)
Explanation
• Biondi ring tangles are intracellular inclusions found in epithelial cells of choroid plexus cells of Alzheimers disease/aging brains
• Biondi ring tangles are intracellular inclusions found in epithelial cells of choroid plexus cells of Alzheimers disease/aging brains
•
They are homogenous globules covered with a thin layer of amyloid fibrils
• By
electron microscopy these tangles are made of tightly packed bundles of long
filaments with diameter around 10 nm that are morphologically distinct
•
Pathological changes in choroid plexus in Alzheimer’s disease
1.
Epithelial atrophy (↓cell size by 1/3)
2.
Biondi ring tangles
3.
Lipofuchsin vacuoles
4.
Basement membrane thickening (3-fold t)
5. Stromal
fibrosis
6.
IgG and 1gM depositions
