Which is associated with nonalcoholic steatohepatitis?
A. Amiodarone therapy
B. Thin body habitus
C. Phenytoin sodium therapy
D. Right hemicolectomy
Ans: (A) Amiodarone therapy
Nonalcoholic steatohepatitis is often
associated with obesity, diabetes mellitus, intravenous hyperalimentation,
jejunoileal bypass surgery, and drugs such as amiodarone. The liver is fatty on
biopsy, and Mallory bodies are occasionally noted. Laboratory examination may
reveal a two- to fourfold increase in transaminase levels. Initially thought
to be a benign condition, prolonged steatohepatitis may lead to cirrhosis.
Treatment consists of reducing risk factors; for example, loss of 10% of body
weight has been associated with a marked improvement of transaminase levels in
obese patients.
