Agammaglobulinemia | Crack PGIMER NOV 2016

All are true regarding agammaglobulinemia except: 

A. Loss of germinal center in lymph node 
B. Normal cortical lymphocytes 
C. Decreased lymphocytes in paracortex and medulla 
D. Decreased red pulp in spleen
E. Immunodeficiency (cell mediated)

The Answer is . (B) Normal cortical lymphocytes; (C) Decreased lymphocytes in paracortex and medulla
(D) Decreased red pulp in spleen ; (E) Immunodeficiency (cell mediated)

• Agammaglobulinemia is a primary humoral immunodeficiency affecting male child older than six months of age. It is X-linked disorder.

• There is failure of B cell precursors (pro-B, pre-B) to differentiate into B-cells, The block in the

differentiation of B-cells is due to mutations in cytoplasmic bruton tyrosine kinase

• Bursa-dependent area shows depletion of cells

• In Lymph node B-cell areas : Cortical follicles, medullary cords

T-cell areas : para cortical areas

• In spleen :B-cell areas: Perifollicular region, germinal centre, mantle layer

T-cell areas red-pulp

• Cell-mediated immunity is nt affected

• As Bursa dependant area cells are affected — so B Cell areas of L.N. and spleen shows depletion of cells.