HMB-45 is immunohistochemistry marker for
A. Melanoma
B. Schwannoma
C. Neurofibrorna
D. Rhabdomyosarcoma
Ans. A. Melanoma.
Explanation
• HMB-45 is immunohistochemical
marker for melanoma
•
HBN-45 is a monoclonal antibody originally, obtained from extract of malignant melanoma,
which identifies an oncofel3l glycoconjugate associated with immature
melanosomes and probably related to the tyrosinase engymatic system
•
Originally thought to be specific for activated neoplastic melanocytes, it is
now known to be expressed by other neural crest derived tumors, angiomyolipomas
of the kidney and other sites,
other components of tuberosus sclerosis complex (“PEComas”) and occassional
carcinomas and other neoplasms.
