Insulin causes increased lipogenesis | NEET Based MCQ

Insulin causes increased lipogenesis by all of following EXCEPT 

A. Inhibition of pyruvate dehydrogenase 
B. Increasing activity of acetyl carboxylase 
C. Decrease of cAMP in cell 
D. Causes glucose to move in the cell

Ans. A. (Inhibition of pyruvate dehydrogenase)

Explanation
Insulin stimulates lipogenesis by the following:

• Increasing acetyl CoA carboxylase activity.

• Increasing transport of glucose into cell (adipose tissue).

• Converts inactive form of pyruvate dehydrogenase to active form in adipose tissue.

• Insulin, by its ability to depress the level of intracellular cyclic AMP and inhibit lipogenesis in adipose tissue, decreases the concentration of plasma FFA and therefore long-chain acetyl CoA, which is the inhibitor of lipogenesis.