Metabolic bone disease | PGI Nov 2017 Preparations MCQ

Metabolic bone disease is caused by excess intake of all of the following vitamins except 

A. A 
B. B 
C. C 
D. D 
E. E

Answer. B. C; E .

• Vitamin-A, intoxication leads to demineralization of bone, hypercalcemia, hyperostosis

• Vitamin- D, intoxication leads to hypercalcemia and hyperphosphatemia.

• High doses of Vit. E (> 800 mg/d) may reduce platelet aggregation and interfere with Vit. K metabolism

• Vit. C toxicity results in

-  kidney stones especially in pre-existing renal disease since Vit. C is metabolised to OXALATE.

- Induction of hemolysis in G-6 PD deficient patients.

- Ealse negative guaiac test.

- Interference with test for urinary glucose.

• Deficiency of Vit. C leads impaired bone growth.