Wednesday 22 June 2016

Dense bodies contain MCQ | Crack PGIMER NOV 2016


Dense bodies contain

A. Fibrinogen 
B. PF 4
C. PDGF 
D. TGF beta
E. Ionized calcium


The answer is. E. Ionized calcium

Platelets are disc-shaped; anucleate cell fragments that areshed from megakaryocytes in the bone marrow into the bloodstream. They play a critical role in normal hemostasis, byforming the hemostatic plug that initially seals vasculardefects, and by providing a surface that recruits andconcentrates activated coagulation factors. Their functiondepends on several glycoprotein receptors, a contractilecytoskeleton, and two types of cytoplasmic granules.α-Granules have the adhesion molecule P-selectin on theirmembranes and contain fibrinogen, fibronectin, factors V andVIII, platelet factor 4 (a heparin-binding chemokine), plateletderivedgrowth factor (PDGF), and transforming growth factor-β (TGF-β). Dense (or δ) granules contain ADP and ATP, ionizedcalcium, histamine, serotonin, and epinephrine.