Thursday 9 June 2016

Pyogenic liver abscess | Crack PGIMER NOV 2016

True about pyogenic liver abscess 

A. Single &large abscess 
B. X ray features arc diagnostic 
C. Serology is confirmatory investigation 
D. Systemic complaints, fever &jaundice common 
E. Liver enzyme abnormalities are common

Answer (D) Systemic complaints, fever & jaundice common (E) Liver enzyme abnormalities are common
-the liver abcess is either single or multiple, sized from few milimeter to many centimeters.
Diagnosis:
-    computed tomography (CT) scan—to locate the abscess
-    CT with intravenous contrast—to pinpoint and measure the abscess (very useful when planning a surgery)
-    blood tests—elevated white blood count and high neutrophil level indicate infection
-    blood cultures for bacteria—to identify the bacteria so your doctor knows what antibiotic to prescribe
-    abdominal ultrasound—to visualize an abscess in the right upper quadrant
Symptoms:
-    chills, vomiting, fever (most common presenting symptom)
-    right upper abdominal pain
-    sudden dramatic weight loss (> 5 kgs in few weeks)
-    dark-colored urine
-    whitish or clay-colored stool
-    Diarrhea
Laboratory findings
-    Hyperbilirubinemia is present in only a small proportion of cases.
-    In acute liver abscess, the aspartate aminotransferase (AST) levels are high.
-    In chronic liver abscess, the alkaline phosphatase level tends to be elevated and the AST level tends to be within normal limits. Overall, the alkaline phosphatase level is elevated in about 70% of cases of amebic liver abscess.
-    Similar CBC count and liver test abnormalities are found in patients with pyogenic liver abscesses and are not specific