S. aureus causes a wide variety of infections, ranging from wound
infection to pneumonia. Treatment of S. aureus infection with penicillin
is often complicated by the
A. Inability of penicillin to penetrate the membrane of S. aureus
B. Production of penicillinase by S. aureus
C. Production of penicillin acetylase by S. aureus
D. Lack of penicillin binding sites on S. aureus
A. Inability of penicillin to penetrate the membrane of S. aureus
B. Production of penicillinase by S. aureus
C. Production of penicillin acetylase by S. aureus
D. Lack of penicillin binding sites on S. aureus
Ans. B.
Staphylococci are Gram-positive,
non-sporeforming cocci. Clinically, their antibiotic resistance poses major
problems. Many strains produce β-lactamase (penicillinase), an enzyme that
destroys penicillin by opening the lactam ring. Drug resistance, mediated by
plasmids, may be transferred by transduction.
