Correct option(s) in context to IgA is/are
A. Is involved in mucosal immunity.
B. Have 4 distinct sub-groups
C. Activates complement via the classical pathway.
D. Is manufactured in lymph nodes.
E. Crosses the placenta.
A. Is involved in mucosal immunity.
B. Have 4 distinct sub-groups
C. Activates complement via the classical pathway.
D. Is manufactured in lymph nodes.
E. Crosses the placenta.
. Ans. A, D
IgA is the major antibody in serology: tears, sweat,
lung,gut, urine. IgA avoids digestion by the presence of thesecretory piece
which is added as it is secreted onto themucosa. It is an important defence
against surface binding of microorganisms. There are 2 sub-types, IgA1and IgA2.
Only IgG is transferred across the placenta.Complement proteins circulate,
therefore, they rarelycome into contact with IgA.
