Risk of malignancy in Ulcerative colitis is more in:
A. Onset in childhoodB. Extensive involvement of colon
C. Disrupted architecture with crypt abscesses
D. Pseudopolyps
E. Recurrence after treatmen
Answer
(A) Onset in childhood; (B) Extensive involvement of colon (E) Recurrence after
treatment
• The risk of cancer in ulcerative colitis is related to the
extent of mucosol involvement (More risk in pancolitis) and to the duration of
the disease, Not in intensity of the inflammation Ca is more likely to occur in the part of colon where disease started in early life.
• Unfortunately, some childhood UC that become
quiescent develop colon cancer in early life (adult)
• Cancer arise from dysplastic areas or it may arise in flat mucosal surface.
