Bismuth subsalicylate is used in the treatment of peptic ulcer primarily because of its ability to:
a. Neutralize gastric acidb. Eradicate Helicobacter pylori
c. Stimulate mucus secretion
d. Inhibit acid secretion
Ans. (B). Eradicate Helicobacter pylori
The
gram-negative bacillus Helicobacter pylori is believed to be a significant
factor in the pathogenesis of duodenal ulcers. Ulcer treatment includes bismuth
salts because they eradicate this organism and are effective in preventing
ulcer recurrences. Bismuth preparations may also coat the ulcer base, adsorb
pepsin, and enhance prostaglandin synthesis.
Bismuth does not directly inhibit acid secretion or pepsin production and it is
not an antacid.
