Hemodialysis is not useful in
a. Benzodiazepinesb. Methanol
c. Digitalis.
d. Theophylline
e. Salicylates
Ans.
(C) Digitalis
• Digoxin having large volume of distribution and hence hemodialysis is not
very effective in removing drug from
body.
• Hemodialysis is effective in poisoning with methanol,
Phenobarbital, Phenytoin, theophylline and salicylate.
Extra corporeal treatment of poisoning: Hemoperfusion, Hemofiltration
Extra corporeal treatment of poisoning: Hemoperfusion, Hemofiltration
|
Drugs related factors
|
Dialysis related factors
|
|
Low mol wt
|
Large surface area of membrane
|
|
Low protein binding
|
High flux dialyzer
|
|
Low vol. of distribution
|
High blood and dialysate flow
rate
|
|
Water soluble
|
Increased ultrafiltration rate
|
