Concomitant use of vaiproic acid and lamotrigine increases the risk of:
a. Chondrodysplasia punctatab. Paroxysmal Nocturnal hemoglobinuria
c. Stevens-Johnson syndrome
d. Floppy infant syndrome
Ans. (C) Stevens-Johnson syndrome
Concomitant use of valproic acid and lamotrigine increases the plasma level of lamotrigine and increases the risk of Stevens Johnson syndrome; hence, lamotrigine should be started as a low dose with gradual escalation.
Concomitant use of valproic acid and lamotrigine increases the plasma level of lamotrigine and increases the risk of Stevens Johnson syndrome; hence, lamotrigine should be started as a low dose with gradual escalation.
