Hereditary spherocytosis is due to deficiency:
a. Spectrinb. Invertin
c. Cytokeratin
d. peptidoglycan membrane protein
e. All of the above
Ans.
is a i.e Spectrin
Hereditary spherocytosis It is characterized by spherical RBC due to a
molecular defect in one of the proteins in the cytoskeleton spectrin of the ABC
membrane; this leads to a loss of membrane and hence decrease ratio of surface
area to volume and consequently spherocytosis. Ankyrin
that makes bridge between spectrin and transmembrane ion transporter.
