Extended spectrum beta lactamase inhibitors | PGIMER Frequently Asked Medical PG topics

Extended spectrum beta lactamase inhibitors: 

a. Imipenem 
b. Ceftazidime 
c. Cefoperazone 
d. Ceftriaxone 
e. Aztreonam

Ans. (A) Imipenem

• ESBL (extended spectrum beta lactamase) are beta-lactamases enzymes that mediate resistance (by hydrolyzing) to

extended-spectrum (third generation) cephalosporins (e g, cefiazidime, cefotaxime, and cefiriaxone), penicillins, narrow spectrum cephalosporins and monobactams (e.g., aztreonam) but do not affect cephamycins (e.g., cefoxitin and cefotetan) or carbapenems (e.g., meropenem or imipenem).

• ESBLs have been reported for E.coli, Kiebsiella Enterobacter, Proteus, Pseudornonas, Salmonella, Serratia and Gram positive organism e g Staphylococcus