Fragmented RBC in peripheral blood | PGI MCQs

Cause of fragmented RBC in peripheral blood 

a. Microangiopathic hemolytic anemia
b. D.I.C 
c. Hemophilia-A 
d. Malignant hypertension 
e. HELLP syndrome

Ans. is a, b, d and e i.e. Microangiopathic hemolytic anaemia; DIC.; Malignant hypertension; and HELLP syndrome
• Fragmented RBC or schistocyte is a characteristic feature of microangiopathic hemolytic anemia as they transverse an abnormal circulation.

• Cause of Fragmented RBC (Microangiopathic hemolytic anemia).

— Hemolytic uremic syndrome (HUS). Thrombotic thrombocytopenic purpura (HP).

— Malignant hypertension. — Eclampsia

— Disseminated intravascular coagulation (DIC). — Disseminated cancer.

— Renal allofgraft rejection.

— Kassabach-Merritt syndrome (giant capillary hemangioma).

— HELLP syndrome (hemolysis, elevated liver enzymes, low platelets).

• In hemolytic anemia, peripheral smear consists of:

— Reticulocytes — Anisocytosis (variation in size)

— Poikilocytosis (variation in shape).