Which one of the listed substances is a serum marker for ventricular dilatation and is used clinically to monitor a patient with congestive heart failure?
A.5'-nucleotidase (5'-NT)B.B-type natriuretic peptide (BNP)
C. Lactate dehydrogenase (LDH)
D. Mannan-binding protein (MBP)
Answer.
B. B-type natriuretic peptide (BNP)
Some myocytes
located within the atrium have specific granules that are the storage sites for
atrial natriuretic peptide (ANP). The actions of ANP include natriuresis,
diuresis, and vasodilation. ANP is increased in patients with hypertension and
congestive heart failure. In the latter it may counteract the effects of the
renin-angiotensin- aldosterone (RAA) and sympathetic systems. B-type
natriuretic peptid levels are sensitive and specific markers of congestive
heart failure and serial measurements may help in the clinical management of
congestive heart failure.
