MHC-class II | PGI Frequently Asked MCQ Topics

True about MHC-class II: 

a. Not involved in innate immunity 
b. Cytotoxic T-cell involved 
c. Present in nucleated cells 
d. Present in B-cells
e. MHC class II-dependent pathway of antigen presentation is called the exogenous pathway.

Ans. (A) Not invoived in innate immunity; (D) Present in B-cells ; E. MHC class II-dependent pathway of antigen presentation is called the exogenous pathway.

* Class II MHC Proteins are glycoprotein present on the surface of certain cells including macrophages, B-cell, dendritic cells of the spleen and langerhans cells of the skin. MHC II located in chromosome no 15,

* Cytotoxic T-cells responed to antigen in association with class I MHC

* Helper T-cell recognises class II. MHC genes and proteins also important in following conditions

- Many autoimmune diseases can occur in people carrying certain types of MHC gene Organ transpiatation.