CAD Predisposing Factors

CAD prédisposing factors: 

a. Homocysteinemia 
b↑ Lipoprotein B 
c↑ Fibrinogen
d↑ HDL 
e↑ plasminogen activator inhibitor-1

Ans. is a, c and e i.e. Homocysteinemla; ↑ fibrinogen and ↑ Plasminogen activator inhibitor-1 Coronary artery disease which implies atherosclerosis of the epicardial coronary arteries is the most common cause of myocardial ischemia.
Predisposing factors of Coronary artery disease

• Hypertension (BP> 140/90mm Hg; >5 fold 1’ risk with BP> 170/95mm Hg)

• Infections (Chlamydia pneumonia, Cytomegalovirus, Herpes).

• Low HDL cholesterol (or low Lipoprotein A, HDL <40mg/dl)

• Increasing age (men > 45yrs; women >55 years).

• High LDL cholesterol (or high Lipoprotein B)

• Cigarette smoking                                             • Diabetes mellitus

• Alcohol intake                                                   • Lipoprotein (a)

• Homocysteinemia                                             •  ↑ fibtinogen levels

• .↓ ↓ - plasmin levels                                      • ↑ ↑ pIasmnogen activator inhibitor-1

• Male gender                                                      • Family history

• Obesity (BMI > 30kg/rn2)                               • Physical inactivity

• Stress (type A personality)                              • Inflammation