What is involved in Formation of d-TMP from d-UMP?
a. N5, N10- methylene tetra hydrofolate
b. Form imino folate c. N5 formyl folate
d. Dihydro folate
e. Cyanocobalamin and tetrahydrofolate
Ans. (A) N5,
N10, Methylenetetrahydrofolate
Thymidylate synthetase is the enzyme used to generate
thymidine monophosphate (dTMP), which is subsequently phosphorylated to
thymidine triphosphate for use in DNA synthesis and repair.
5,10-methylenetetrahydrofolate + dUMP 
dihydrofolate
+ dTMP
dihydrofolate
+ dTMP