Neostigmine can reverse the actions of the following skeletal muscle relaxants, except:
A. D-tubocurarine
B. Succinylcholine.C. Gallamine.
D. Pancuronium.
Ans.
B. Succinylcholine.
Neostigmine is a reversible
anticholinesterase that prevents the hydrolysis of acetylcholine thus preserves
endogenous acetylcholine. In addition they can directly act on the
neuromuscular junction. Thus they are useful in overdosage of skeletal muscle
relaxants that produce competitive blockade at the neuromuscular junction e.g.
tubocurarine, gallamine, pancuronium, etc. They have a synergistic action with
the skeletal muscle relaxants that act by depolarization. They do not reverse
but can enhance the neuromuscular blockade produced by depolarizing agents for
e.g. succinyicholine.
