Drugs which act by intercalating with DNA | PGIMER entrance Preparations

Drugs which act by intercalating with DNA :

A. Actinomycin D 
B. Tetracycline. 
C. Bleomycin 
D. Doxorubicin. 
E. Doxycycline

Ans. A. Actinomycin D ; (C) Bleomycin; (D) Doxorubicin:

• Actinomycin D, Doxorubicin, Bleomycin-all causes intercalation between DNA strands thereby inhibits RNA, and DNA synthesis. 

• They can alter DNA structure replication and topoisomerase function.