Drug clinically interacting with ribosomes to interfere with translation in bacteria
A. Tetracycline
B. Erythromycin C. Puromycin
D. Oligomycin
E. Penicillin
Ans.
A. Teracycline ; (B) Erythromycin :
• The process of translation is divided into :
— Initiation
— Elongation
— Termination.
, Streptomycin binds to the 30 S sub-units and distorts its structure,
interfering with the initiation of protein synthesis.
• Tetracyclines interact with small ribosomal sub-units blocking access of the
amino-acyl t-RNA to the m-RNA rihosome complex.
• Puromycin, chloramphenicol inhibits elongation.
• Clindamycin Erythromycinbindirreversibly
to a site of 50S subunit of the bacterial ribosome and inhibit translation.Though
puromycin inhibits translation it does not interfere with ribosomes.
