NIME Next Batch PGI Quest in Delhi from 10 August to 20 August
A. 50% carriers, 50% affected
B. 25% carriers, 75% affected
C. 75% carriers, 25% affected
D. All are carriers
E. All are affected
A pt. of cystic fibrosis (homozygous) married a carrier (heterozygous). The chances of developing cystic fibrosis in the offsprings is
A. 50% carriers, 50% affected B. 25% carriers, 75% affected
C. 75% carriers, 25% affected
D. All are carriers
E. All are affected
Ans. A. 50%
carriers, 50% affected
• Cystic fibrosis is an autosomal recessive disorder. Imprtant featrure of AR disease:
- Either sex affected with equalfrequency or severity.
- Affected person is homozygous or compound heterozygote for a-single gene deftet.
- Heterczygous carriers of a deft ctive allele are usually clinically normal.
- Horizontal pattern ofpedigree with a single generation affected.
• The chance of developing cystic fibrosis in our question is 50%.
• Cystic fibrosis is an autosomal recessive disorder. Imprtant featrure of AR disease:
- Either sex affected with equalfrequency or severity.
- Affected person is homozygous or compound heterozygote for a-single gene deftet.
- Heterczygous carriers of a deft ctive allele are usually clinically normal.
- Horizontal pattern ofpedigree with a single generation affected.
• The chance of developing cystic fibrosis in our question is 50%.
