NIME Next Batch PGI Quest in Delhi from 10 August to 20 August
B. Heparin cofactor II
C. Alpha2 antitrypsin
D. Alpha2 macroglobulin
Thrombin activity is inhibited by
A. ChymotrypsinB. Heparin cofactor II
C. Alpha2 antitrypsin
D. Alpha2 macroglobulin
Ans. B. (Heparin cofactor II)
Explanation
• Thrombin activity is inhibited by
• Thrombin activity is inhibited by
1.
Heparin cofactor II
2.
Alpha- 1 antitrypsin and
3.
Antithrombin III
•
Direct thrombin inhibitors such as bivalirudin, lepirudin, and argatroban are a
new class of anticoagulants.
• The mechanism of action of these agents differs from heparin in that they directly inhibit the active site of thrombin, and they do not require an interaction with antithrombin III to produce their anticoagulant effect.
• Furthermore, contrary to heparin, direct thrombin inhibitor agents inhibit only the activity of thrombin whereas heparin, through its activation of antithrombin III, indirectly inhibits factors ha (thrombin), Xa, IXa, XIa and XIIa.
• The mechanism of action of these agents differs from heparin in that they directly inhibit the active site of thrombin, and they do not require an interaction with antithrombin III to produce their anticoagulant effect.
• Furthermore, contrary to heparin, direct thrombin inhibitor agents inhibit only the activity of thrombin whereas heparin, through its activation of antithrombin III, indirectly inhibits factors ha (thrombin), Xa, IXa, XIa and XIIa.
