NIME Next Batch PGI Quest in Delhi from 10 August to 20 August
B. Plasmalogen
C. Cardiolipin
D. Sphingomyelin
Ans. D. Sphingomyelin
• Accumulation of galactocerebroside occurs in Krabbe disease, which is due to galactocerebrocide deficiency.
• Accumulation of glucocerebroside occurs in Gaucher disease, which is due to defects in 13 glucocerebrosidase. The reticuloendothelial cells and CNS are affected.
• Accumulation of GM2 ganglioside occurs in Tay-Sachs disease because of hexosaminidase A deficiency. The swollen ganglion cells of the retina contribute to a classic sign of Tay-Sachs---the macular cherry-red spot.
• Accumulation of sphingomyelin in a variety of organs occurs in Niemann-Pick disease, which is due to a defect in sphingomyelinase.
• Accumulation of sulfatide occurs in Metachromatic leukodystrophy, caused by arylsulfatase A deficiency.
In Niemann picks disease, the main phospholipids abnormally deposited in brain, spleen and liver is:
A. LecithinB. Plasmalogen
C. Cardiolipin
D. Sphingomyelin
Ans. D. Sphingomyelin
• Accumulation of galactocerebroside occurs in Krabbe disease, which is due to galactocerebrocide deficiency.
• Accumulation of glucocerebroside occurs in Gaucher disease, which is due to defects in 13 glucocerebrosidase. The reticuloendothelial cells and CNS are affected.
• Accumulation of GM2 ganglioside occurs in Tay-Sachs disease because of hexosaminidase A deficiency. The swollen ganglion cells of the retina contribute to a classic sign of Tay-Sachs---the macular cherry-red spot.
• Accumulation of sphingomyelin in a variety of organs occurs in Niemann-Pick disease, which is due to a defect in sphingomyelinase.
• Accumulation of sulfatide occurs in Metachromatic leukodystrophy, caused by arylsulfatase A deficiency.
