Monday 5 June 2017

Main function of Apoprotein C | DNB Based MCQ

NIME Next Batch PGI Quest in Delhi from 10 August to 20 August


Which of the following is true regarding the main function of Apoprotein C

A. Cholesterol synthesis 
B. TG transport 
C. Increases activity of Lipoprotein lipase 
D. Fatty acid synthesis


Ans. C. (Increases activity of lipoprotein lipase)
Explanation
• Lipases hydrolyze blood triacylglycerols for their fatty acids to become available to tissues.
• Lipoprotein lipase hydrolyzes triacyiglycerols in plasma lipoproteins. Lipoprotein lipase is located on the surface of endothelial cells of capillaries and possible of adjoining tissue cells.
• It hydrolyzes fatty acids from the 1 and! or 3 positions of tn- and diacylglycerols present in VLDL or chylomicrons.
• One of the lipoprotein apoproteins (Apo C-lI) must be present to activate the process. Fatty acids released are either bound to serum albumin or taken up by the tissue.

• Apoprotein C along with phospholipids helps in activating lipoprotein lipase for catalyzing the conversion of Chylomicrons and VLDL into Chylomicron and VLDL remnants.