Syndrome of Inappropriate ADH secretion (SIADH) | NEET Based MCQ

NIME Next Batch PGI Quest in Delhi from 10 August to 20 August

Which of the following chemotherapy agent can cause syndrome of Inappropriate ADH secretion (SIADH)? 


A. Vincristine 
B. Vinblastine 
C. Dacarbazine 
D. Cyclophosphamide

Ans. A. Vincristine 
Causes of SIADH:
Neoplasms:
Carcinoma - lung, duodenum, pancreas, ovary, Mesothelioma, Branchial adenoma, Carcinoid, Ewing sarcoma
Head trauma
Infections- Pneumonia
                Abscess (lung or brain)
                Cavitation (aspergillosis)
                TB (lung or brain)
                Meningtis (Bacterial or viral)

Encephalitis
                AIDS
Vascular:
Cerebrovascular occlusions, hemorrhage, Cavernous sinus thrombosis
Neurologic:
CBS, MS, ALS, Delirium tremens, Hydrocephalus, Psychosis, Peripheral neuropathy.
Metabolic:
Acute intermittent prophyria
Pulmonary:
Asthma
Pneumothorax
Positive pressure ventilation
Drugs:.
Vasopressin or Desmopressin
Chlorpropamide

Vincristine, Cyclophosphamide
Carbamazepine
Phenothiazines
TCAs
MACIs
SSRIs