NIME Next Batch PGI Quest in Delhi from 10 August to 20 August
A. Heterotopic calcification
B. ↓ed Ca2’
C. ↓edPO
D. ↓ed PTH
E. ↓ed response of urinary cAMP on PT
Which of the following is/are true about pseudohypoparathyrodism?
A. Heterotopic calcification
B. ↓ed Ca2’
C. ↓edPO
D. ↓ed PTH
E. ↓ed response of urinary cAMP on PT
Ans. A. Heterotopic calcification ; (D) ↓ed PTH
Pseudohypoparathyridism is a hereditary disorder characterised by symptoms and signs of hypoparathyroidism, typically in association with distinctive skeletal and developmental defects. The hypoparathyrodism is due to deficiency of endorgan response to PTH. Hyperplasia of parathyroids, in response to hormone resistance, causes elevation of PTH levels. There are hypocalcemia, hyperphosphaemia, heterotropic calcfication and skeletal abnormalities.
— Defects in metatarsals and metacarpals with sometimes short phalanges.
— Typically short 4th and 5th metacarpals and metatarsals bilaterally.
— Exostoses and radius curvtis.
Pseudohypoparathyridism is a hereditary disorder characterised by symptoms and signs of hypoparathyroidism, typically in association with distinctive skeletal and developmental defects. The hypoparathyrodism is due to deficiency of endorgan response to PTH. Hyperplasia of parathyroids, in response to hormone resistance, causes elevation of PTH levels. There are hypocalcemia, hyperphosphaemia, heterotropic calcfication and skeletal abnormalities.
— Defects in metatarsals and metacarpals with sometimes short phalanges.
— Typically short 4th and 5th metacarpals and metatarsals bilaterally.
— Exostoses and radius curvtis.
—Impaired
olfaction and taste and unusual dermatoglyphic abnormalities.
