In anoxia of liver, necrosis is seen in:
A. CentrilobularB. Around the periphery
C. Around the central vein
D. Around the bile duct
E. around the central artery
Ans. C. Around the central vein:
• The histological hallmark of ischemic hepatitis or shock1iver is zone three necrosis.
• Depending upon the degree of ischemia, a variable degree of architectual collapse around the central vein may occur with severe and prolonged ischemia. Necrosis may extended to the midzonal hepatocytes.
• The histological hallmark of ischemic hepatitis or shock1iver is zone three necrosis.
• Depending upon the degree of ischemia, a variable degree of architectual collapse around the central vein may occur with severe and prolonged ischemia. Necrosis may extended to the midzonal hepatocytes.
Note: Functions of different zone of liver.
Zone 1 — Glycogen synthesis and glycogenolysis inhibitor-I:
— Main area for protein metabolism
— Formation of plasma protein
— Conjugation of certain drugs.
Zone 3 —* Glycogen storage
Lipid and pigment formation metabolism of certain drugs and chemicals.
Zone 2 -4- Share functions of both zones.
— Main area for protein metabolism
— Formation of plasma protein
— Conjugation of certain drugs.
Zone 3 —* Glycogen storage
Lipid and pigment formation metabolism of certain drugs and chemicals.
Zone 2 -4- Share functions of both zones.
