Which of the following changes do not occur in malignant hypertension?
A. Segmental dilation of vesselsB. Fibrinoid necrosis of arteriol
C. Intimal thickening of arteriol
D. Hyaline arteriosclerosis
Ans. D. (Hyaline arteriosclerosis)
Explanation
• Malignant nephrosclerosis is the form of renal disease associated with the malignant or accelerated phase of hypertension.
1. Fibrinoid necrosis of arterioles: In malignant hypertension, small muscular arteries show segmental dilation due t necrosis of smooth muscle cells. Endothelial integrity is lost in these regions and increased vascular permeability leak to entry of plasma proteins into the vessel wall, deposition of fibrin, and an appearance termed as fibrinoid necrosis.
• Malignant nephrosclerosis is the form of renal disease associated with the malignant or accelerated phase of hypertension.
1. Fibrinoid necrosis of arterioles: In malignant hypertension, small muscular arteries show segmental dilation due t necrosis of smooth muscle cells. Endothelial integrity is lost in these regions and increased vascular permeability leak to entry of plasma proteins into the vessel wall, deposition of fibrin, and an appearance termed as fibrinoid necrosis.
2.
In the interlobular arteries and arterioles, there is intimal thickening caused
by a proliferation of elongated, concennically arranged smooth muscle cells,
together with fine concentric layering of collagen and accumulation of pale
stainii material that likely represents accumulations of proteoglycans and
plasma proteins. This alteration has been referred s as onion-skinning
(hyperplastic arteriolopathy) because of its concentric appearance. Other
changes include necrotisir. glomerulitis
and glomerular thrombotic microangiopathy.
3.
In benign nephrosclerosis, on histologic examination of kidney, there is
narrowing of the lumens of arterioles and sm arteries, caused by thickening and
hyalinization of the walls (hyaline
arterioloselerosis)
