All are true for immuno suppressants except:
A. Sirolimus acts by I cell modificationB. Tacrolimus inhibits calcineuiin pathway
C. Mycophenolate acts by inhibiting GMP dehydrogenase
D. Cyclosporin is integral in transplant rejection regimen.
Ans.
C.
Mycophenolate is a prodrug of mycophenolic acid which
selectively inhibits inosine monophosphate dehydrogenase thus inhibiting
lymphocyte proliferation, antibody production and cell mediated immunity.
Available in oral &iv forms.
• Newer applications are lupus nephritis, RA & some skin conditions.
Cyclosporin:
Mech. of Action: enters target cells and binds to a protein cyclophilin forming
a complex which inactivates calcineurin -1 gene transcription of IL-2/3, INF-alpha) Response of T helper cells to
antigenic stimulation fails
• Selectively increases cell mediated immunity
• S/E: Nephrotoxicity, increase
in BP, Hyperkalemia Hepatotoxicty, pecipitation of OMHirsuitism, gum
hyperplasia, tremors
Uses:
i. Prevents graft rejection (most effective drug for it)
ii. Autoimmune diseases (RA, 180 etc)
iii. Psoriasis
iv. Aplastic anemia
