Wednesday, 15 March 2017

Vasculitis | PGI May 2017


Vasculitis is seen in 

A. Burger’s disease 
B. HSP 
C. Gout 
D. Reiter’s disease 
E. Behcets syndrome



Ans. A. Burger’s disease ; (B) HSP; (D) Reiter’s disease ; (E) Behcet’s syndrome
Classification of vasculitis
I. Systemic necrotizing vasculitis
A. Poly arteritis nodosa (PAN)
1. Classic PAN
2.Microscopic polyangitis
B. Allergic angitis and granulomatosis of churg strauss
C. Polyangitis overlap syndrome.
II. Wegener’s granulomatosis.
III. Temporal arteritis
IV. Takayasu’s arteritis
V. Henoch-Schonlein purpura.
VI. Predominantly cutaneous vasctilitis. (hypersensitivity vasculitis)
A. Exogenous stimuli suspected
1. Drugs-induced vasculitis.
2. Serum sickness and serum sickness like reaction.
3. Vasculitis associated with infection disease
B. Endogenous antigen likely involved
1. Vasculitis associated with neoplasm.

2. Vasculities associated with connective tissue disease e.g. RA, SLE, sjogren syndrome.
3. Vasculitis associated with underlying disease e.g. SBE, EB virus infection HIV infection, ulcerative coilits ; congenital deficiencies of various complement components, retroperitonial fibrosis and primary biliary cirrhosis. Predominantly cutanous vasculitis with α-antitrypsin deficiency ;intestinal bypass surgery, and relapsing polychondritis.
4. Vasculitis associated with congenital deficiency of complement system.
VII. Other vaculitis syndrome
A. Kawasaki disease
B, Isolated central nervous system vasculitis
C. Thromboangiitis obliterans (Burger’s disease)
D. Behcet’s syndrome
E. Miscellaneous vascutilis
Direct infection related to vasculitis,
Bacterial (e.g. — Neisseria)
Rickettsial (e.g. Rocky Mountain spotted fever)
Spirochetal (e.g. syphilis)
Fungal (e.g. aspergillosis, murmor mycosis)
Viral (e.g. Herpes Zoster, variable hepatitis virus infection)
 → The seronegative arthropathies, amkylbsing spondylitis, Reiter’s Syndrome, Psoriatic arthrits and arthrities associated ulcerative colitis and regional enteritis may be accompained by paricarditis and
Proximal aoritis.