ACE inhibitor induced cough is mediated by.
A. Bradykinin
B. Substance - P
C. Prostaglandin
D. Serotonin
E. Renin
Ans.
A. Bradykinin ; (B) Substance—P ; (C)
Prostaglandin
•About
5-20% of patients taking ACE
inhibitors develop a non-productive cough. Onset is usually within 1 week of starting the drug but can be delayed
up to 6 months. Mechanism is not known with certainty, but may be due to accumulation
of bradykinin, substance-P, and / or prostaglandin which are degraded by
ACE.
• Treatment:Cough disappears within 4
days if stoppage. Sometime require cessation of therapy.
• Thromboxane antagonism reduces ACE inhibitor induced cough.
